A follicular B cell surface marker expressed in early lymphoid progenitors and normal germinal center cells. Almost always present on the surface of precursor B-lymphoblastic and Burkitt lymphomas but much less frequently present on precursor T-lymphoblastic leukemia-lymphoma. It is also expressed in a subset of non-hematopoietic tumors, including atypical fibroxanthoma, and is positive in many follicular lymphoma and some diffuse large B-cell lymphomas and multiple myeloma. It is a good marker of endometrial stomal sarcoma and is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, and highly expressed on the brush border of kidney and gut epithelial cells.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.