A cell surface transmembrane protein predominantly found in the gastrointestinal tract and gall bladder which identifies renal cell carcinoma as well as other clear cell carcinomas, e.g. from urothelium and adrenal cortex. In the case of adenocarcinoma, the glandular regions of the colon are positive. This protein is also expressed in common epithelial tumors such as carcinomas of the esophagus, lung, colon, kidney, cervix, and non-small cell lung carcinoma, while expression is absent in normal kidney, chromophobe carcinomas, or oncocytomas.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.