A smooth muscle specific cytoskeletal protein involved in the regulation of smooth muscle contraction that is useful in the identification of smooth muscle tumors and myoepithelium. It is also a useful tool to demonstrate the presence of myoepithelium around suspicious cell nests and helps distinguish in situ from invasive lesions when part of a panel. Two isoforms of calponin exist, and the expression of the 29kDa form is primarily restricted to muscle of the urogenital tract.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.