Identifies a glycoprotein present on the surface and the cytoplasm of all epithelial cells except the superficial layers of squamous epithelial, hepatocytes, and parietal cells. It is expressed in the vast majority of adenocarcinoma but does not label mesothelial cells and is almost always negative in mesothelioma. It also reportedly distinguishes adenocarcinomas from pleural mesotheliomas.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.