BAP1 functions as a tumor suppressor gene, and the loss of this gene is 100% specific for malignant mesothelioma in the context of mesothelial hyperplasia. When the stain is combined with p16 FISH, it separates benign mesothelial proliferations from malignant ones, especially when invasion by mesothelial cells cannot be demonstrated.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.