Identifies cells responsible for the regulation of the growth of the prostate epithelial cells, positive in a subset of carcinomas, including those primary to the breast, salivary gland, and prostate. In untreated prostate carcinoma, AR positive cells are more likely to be responsive to hormonal therapy, while in hormone refractory prostate carcinoma, the presence of AR has a negative prognostic impact.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.