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Highlights intracytoplasmic globules seen in alpha-1-antitrypsin deficiency, as well as in benign and malignant liver tumors and yolk sac carcinoma. Can aid in evaluating patients with unexplained cirrhosis or liver disease characterized by portal fibrosis of unclear origin.Identifies intracytoplasmic globules in the context of alpha-1-antitrypsin deficiency, benign and malignant hepatic tumors, and yolk sac carcinoma. Useful for screening patients with cryptogenic cirrhosis or other forms of liver disease with portal fibrosis of uncertain cause.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2charged slides per stain requested (minimum of 1 slide per stain),baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.